Week 3 Objectives - Organic Chemistry II UC-Berkeley...

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Page 1 of 2 Organic Chemistry II UC-Berkeley Extension, Spring 2011 February 2, 2011 Week 2: acetals as protecting groups, imines/Schiff bases, acidity of ! -hydrogens, keto-enol-tautomerism, racemization, ! -halogenation, oxidations, hydride reductions, catalytic reduction. Carboxylic Acids: nomenclature, physical properties, pKa, reactions with bases, synthesis from Grignard reagents, reduction, NADH, Fischer esterification, acid chlorides, decarboxylation. Objectives: Use an acetal appropriately as a protecting group for an aldehyde or ketone in a multi- step series of reactions. Draw the mechanism showing formation of an imine (i.e. a Schiff base) from a primary amine and an aldehyde or ketone. Describe the synthetic usefulness of imines. Describe in general terms a common use of imines in proteins. Contrast the acidity of an ! -hydrogen in an aldehyde or ketone with an alkane hydrogen. Explain how stabilization of the conjugate base of an aldehyde or ketone
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This note was uploaded on 01/22/2012 for the course CHEM II taught by Professor G during the Fall '11 term at University of California, Berkeley.

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Week 3 Objectives - Organic Chemistry II UC-Berkeley...

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