This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: contain ergosterol instead of cholesterol. However, these antibiotics are potentially quite toxic to the host. Examples are the polymixins, and antifungals such as amphotericin B, miconazole, and ketoconazole. 4. I NHIBITION OF NUCLEIC ACID SYNTHESIS---selective toxicity varies, but these interfere with DNA replication and transcription. Rifampin and the quinolones are examples. 5. I NHIBITING THE SYNTHESIS OF ESSENTIAL METABOLITES---the sulfas and trimethoprim work this way. They interfere with the pathway by which bacteria synthesize folic acid. Since humans produce folic acid by a different pathway, these drugs have less effect on human cells....
View Full Document
- Fall '09
- streptomycin, trimethoprim, transcription. Rifampin, PROTEIN SYNTHESISsince ribosomes