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Unformatted text preview: contain ergosterol instead of cholesterol. However, these antibiotics are potentially quite toxic to the host. Examples are the polymixins, and antifungals such as amphotericin B, miconazole, and ketoconazole. 4. I NHIBITION OF NUCLEIC ACID SYNTHESIS---selective toxicity varies, but these interfere with DNA replication and transcription. Rifampin and the quinolones are examples. 5. I NHIBITING THE SYNTHESIS OF ESSENTIAL METABOLITES---the sulfas and trimethoprim work this way. They interfere with the pathway by which bacteria synthesize folic acid. Since humans produce folic acid by a different pathway, these drugs have less effect on human cells....
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This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.
- Fall '09