ACTION OF ANTIMICROBIAL DRUGS - contain ergosterol instead...

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ACTION OF ANTIMICROBIAL DRUGS   Antimicrobial drugs are either   ---cidal, which means they actually kill the pathogens, or  ----static, which means they slow or prevent reproduction. In either case, the defenses of the host  will also be needed.   1. I NHIBITION   OF   CELL   WALL   SYNTHESIS SINCE  this attacks the cell wall, these drugs have little effect  on host cells, which do not contain peptidoglycan. Penicillin, bacitracin, and vancomycin act in  this way.   2. I NHIBITION   OF   PROTEIN   SYNTHESIS ---since ribosomes of procaryotic cells are slightly different from  those of eucaryocytes, they can be used as a target. Chloramphenicol, erythromycin,  streptomycin, and the tetracyclines act in this way.   3. I NJURY   TO   THE   PLASMA   MEMBRANE —this is a mode of action of both some antibacterials and some  antifungals. Antifungals are able to work mostly against fungus cell membranes because they 
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Unformatted text preview: contain ergosterol instead of cholesterol. However, these antibiotics are potentially quite toxic to the host. Examples are the polymixins, and antifungals such as amphotericin B, miconazole, and ketoconazole. 4. I NHIBITION OF NUCLEIC ACID SYNTHESIS---selective toxicity varies, but these interfere with DNA replication and transcription. Rifampin and the quinolones are examples. 5. I NHIBITING THE SYNTHESIS OF ESSENTIAL METABOLITES---the sulfas and trimethoprim work this way. They interfere with the pathway by which bacteria synthesize folic acid. Since humans produce folic acid by a different pathway, these drugs have less effect on human cells....
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This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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ACTION OF ANTIMICROBIAL DRUGS - contain ergosterol instead...

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