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Unformatted text preview: immune responses. Staphylococcal toxins act this way. Some major exotoxins: 1. Diphtheria toxin---Corynebacterium diphtheriae produces this toxin when it is carrying a lysogenic phage which includes the tox gene. This is a cytotoxin which inhibits protein synthesis as follows: a. The toxin consists of 2 different polypeptides combined, A (active) and B (binding). A is the one which actually causes the harm to the host, but it cannot act without B also being present. b. Polypeptide B binds to surface receptors on the host cell and causes the transport of both parts across the plasma membrane into the cell. c. The two parts separate d. Polypeptide A inhibits protein synthesis inside the cell....
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- Fall '09