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Unformatted text preview: leukotrienes and prostaglandins. The chemical mediators cause increased permeability of capillaries, increased secretion of mucus, smooth muscle contraction, etc. a. Systemic anaphylaxisvery large amounts of the chemical mediators are released and cause circulatory collapse and constriction of air passages which may lead to death. Epinephrine can counteract this. b. Local anaphylaxisless severe, less release of mediators. Usually associated with ingested or inhaled antigens. Effects include hives, asthma, hay fever, gastrointestinal upsets, etc. Repeated injections of tiny amounts of the allergen may succeed in desensitization. IgG antibodies are formed, which block the antigen by binding to it before it can reach the IgEs....
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- Fall '09