MONOCLONAL ANTIBODIES

MONOCLONAL ANTIBODIES - MONOCLONALANTIBODIES

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MONOCLONAL ANTIBODIES   In addition to body defense, antibodies are also very helpful in diagnosis of disease. For some  time, the procedure for obtaining them involved injection of the antigen into an animal, which  stimulated the animal to produce antibodies which could be recovered from the serum. This did  not result in great amounts of the antibody, and it was difficult to isolate one particular antibody  from other antibodies in the serum.    In 1984, three immunologists received the Nobel Prize for their discovery of a method by which  a B cell could be treated so that it would divide indefinitely when removed from the body and  grown in tissue culture. This involved combining a cancerous B cell, which would divide  indefinitely, and a normal B cell which would produce the antibody desired. This resulted in a  hybridoma, which would grow and produce antibodies indefinitely. Since all the antibodies come 
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This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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MONOCLONAL ANTIBODIES - MONOCLONALANTIBODIES

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