OTHER ANTIMICROBIALS MODE OF ACTION COMMENTS ANTIFUNGAL DRUGS P OLYENES Amphotericin B Injury to plasma membrane Systemic fungal infections. Fungicidal. I MIDAZOLES TRIAZOLES Inhibition of plasma membrane synthesis. Fungicidal. Clotrimazole Topical use for fungal infections of skin and mucous membranes. Possibly fungicidal. Ketoconazole Topical use for fungal infections of skin; orally for systemic fungal infections. Fungistatic. Griseofulvin Inhibition of mitotic spindle. Rungal infections of skin. Fungistatic. Tolnaftate Unknown. Athlete’s foot. Fungicidal. Flucytosine Inhibits DNA or RNA synthesis. Systemic fungal infections. Fungicidal. ANTIVIRAL DRUGS Amantadine Blocks entry or uncoating. Influenza A prevention . N UCLEOSIDE ANALOGS Acyclovir, ribavirin, ganciclovir, trifluoridine Inhibit DNA synthesis by reverse transcriptase Herpesvirus
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World Health Organization essential medicines, Amantadine, Tolnaftate, Systemic fungal infections., fungal infections. Fungicidal