PATHOGENIC PROPERTIES OF VIRUSE1

PATHOGENIC PROPERTIES OF VIRUSE1 - PATHOGENIC PROPERTIES OF...

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PATHOGENIC PROPERTIES OF VIRUSES   Viruses must gain access to the host, evade the host’s defenses, and cause damage or death to the  host cell while reproducing themselves.       1. Viral mechanisms for evading host defenses---viruses have attachment sites for receptors on  host cells. This allows the virus to bind to and penetrate the cell. Once it is inside, it is protected  from host defenses. Some viruses manage to enter cells by mimicking a substance useful to the  cell and using the receptor for that substance. For example, the rabies virus mimics acetylcholine  and enters cells that way. The AIDS virus has attachment sites complementary to the CD4  protein found on human cells, mainly on T lymphocytes. The virus can attach to these receptors  and enter cells. Antibodies are produced but are not very effective because the antibodies cannot  reach the attachment sites.
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