STAGES OF INFLAMMATION - dead neutrophils The macrophages...

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STAGES OF INFLAMMATION 2. P HAGOCYTE   MIGRATION   AND   PHAGOCYTOSIS ---phagocytes generally appear within one hour or less.  Neutrophils are usually the first to arrive in large numbers. They move through the blood vessels  to the damaged area, and then begin to stick to the endothelium of the blood vessels  (margination). They begin to squeeze between the endothelial cells to travel to the damaged area.  This is called emigration or diapedesis. The neutrophils mainly carry out phagocytosis of  bacteria. Monocytes are also attracted to the damaged tissue, where they leave the blood and  become wandering macrophages. They can phagocytize damaged tissue as well as microbes and 
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Unformatted text preview: dead neutrophils. The macrophages also eventually die and contribute to the formation of pus. Phagocytosis is essential to body defense. Unfortunately, a number of things can suppress it: • Genetic defects • Old age • Anti-rejection drugs in transplant recipients • Radiation • AIDS • Cancer 3. T ISSUE REPAIR---repair cannot proceed well until microbes as well as dead or damaged tissue have been removed by phagocytes. Tissues vary in their ability to replace dead cells with new cells of the same type, which is called regeneration. If scar tissue makes up most of the repair, some function will be lost....
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