THE TRANSFORMATION OF NORMAL CELLS INTO TUMOR

THE TRANSFORMATION OF NORMAL CELLS INTO TUMOR - cells 3...

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THE TRANSFORMATION OF NORMAL CELLS INTO TUMOR                                                     CELLS Anything that alters the genetic material of a cell has the potential to change a normal cell into a cancer cell. The part of the genome that is affected are genes known as oncogenes. Viruses capable of inducing tumors are called oncogenic viruses. They probably account for around 10% of human cancers. Genetic material of oncoviruses integrates into the host cell’s DNA and replicates along with the host cell chromosomes. Cells that have been changed to tumor cells are said to be transformed.   1. Transformed cells tend to divide in an uncontrolled rapid way.  2. They tend to have chromosome abnormalities and possibly a different shape than normal 
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Unformatted text preview: cells. 3. They lose the characteristic of contact inhibition. This means that instead of forming a single layer of cells when grown in tissue culture, transformed cells tend to form tumor-like masses of cells piled up on each other. 4. Transformed cells may cause tumors when injected into susceptible animals. 5. Many tumor cells that have been transformed by viruses display a virus-specific antigen on their surface called tumor-specific transplantation antigen (TSTA) or an antigen in the nucleus called the T antigen. 6. Transformed cells tend to be less round than normal cells and often ixibit chromosomal abnormalities....
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