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Unformatted text preview: success of chemotherapy is that some chemicals are more poisonous to microbes than to the host infected by the microbe First Synthetic Drug- First chemotherapyused substances from nature such as plant products (folk medicine) Cinchona barkquinine for malaria Willow barkaspirin Foxglovedigitalis, congestive heart failure and diurectic against dropsy (excess fluid build-up in tissues) 1910, Paul Ehrlich found Salvarsan (arsenic derivative) effective against syphilis 1930s sulfa drugs (sulfonamides) synethisized 1928, Alexander Fleming discovered penicillin by accident. Fungus infected his bacterial plates and inhibited the growth of his bacteria- Penicillin not extensively tested or mass produced until 1940s...
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- Fall '09