CLONAL SELECTION THEORY AND ACTIVATION OF ANTIBODIES

CLONAL SELECTION - combines with a particular antigen for which its antibody fits it will be stimulated to reproduce a clone of itself which will

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
CLONAL SELECTION THEORY AND ACTIVATION OF ANTIBODIES During fetal development specialized cells of the developing immune system move about the body and desensitize to self proteins. In other words, the fetal immune system recognizes self from antigen and this lasts throughout life. Any self antigens which will stimulate an immune response are somehow destroyed during this period. There is an area of the DNA in precursor cells of the lymphocytes which produce antibody shapes. The DNA mutates to the point of producing a large number of B lymphocytes (one of two categories of lymphocytes, the other being T) which then can produce a large number of different types of antibodies. Many of these antibodies are expressed on the surface of the B cell (They poke out). If a B cell
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: combines with a particular antigen for which its antibody fits it will be stimulated to reproduce a clone of itself which will produce a large number of this antibody. Hence we account for large numbers of specific antibodies. The role of T cells is to stimulate the B cells and activate them by producing chemicals (chemokines) which act as cellular hormones. The T cells get stimulated by Macrophage which digest foreign cells and present antigen to T cells by direct contact. After this process some B cells of the specific antigen producing type remain as memory cells. Other B cells were stimulated by antibody and T cells to become plasma cells which produce antibody....
View Full Document

This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

Ask a homework question - tutors are online