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Unformatted text preview: 3. Type I IgE Mediated a. IgE attaches to membrane of mast cells b. Location mast cells skin, m.m. of R.T. and G.I. tract, endothelium, smooth muscles (internal organs) c. Development 1). Primary exposure: a). Exposed to allergen first time b). Production IgE antibodies c). IgE attaches to membrane mast cells sensitized 2). Subsequent exposure: a). Allergen comes in contact with sensitized tissues b). Allergen reacts with IgE on mast cells c). Ag-Ab reaction causes lysis cell membrane d). Mast cells release granules degranulation e). Granules broken down in tissues f). Release histamine, heparin, and other chemicals g). Physiological effects: [ 1 ] . Vasodilation [ 2 ] . Vascular permeability [ 3 ] . Mucus secretions [ 4 ] . Smooth muscle contraction [ 5 ] . Anticoagulation (heparin)...
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This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.
- Fall '09