This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: 3. Type I – IgE Mediated a. IgE attaches to membrane of mast cells b. Location mast cells – skin, m.m. of R.T. and G.I. tract, endothelium, smooth muscles (internal organs) c. Development 1). Primary exposure: a). Exposed to allergen first time b). Production IgE antibodies c). IgE attaches to membrane mast cells → “sensitized” 2). Subsequent exposure: a). Allergen comes in contact with “sensitized” tissues b). Allergen reacts with IgE on mast cells c). Ag-Ab reaction causes lysis cell membrane d). Mast cells release granules – degranulation e). Granules broken down in tissues f). Release histamine, heparin, and other chemicals g). Physiological effects: [ 1 ] . Vasodilation ↑ [ 2 ] . Vascular permeability ↑ [ 3 ] . Mucus secretions ↑ [ 4 ] . Smooth muscle contraction ↑ [ 5 ] . Anticoagulation (heparin)...
View Full Document
- Fall '09
- mast cells, IgE