Delayed - 3). Lymphokines: a). Transfer factor sensitizes...

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Delayed-type Hypersensitivities (Type IV) 1. General Characteristics: a. Allergens - whole cells, haptens that complex with skin proteins b. Route of exposure - subcutaneous tissues, internal tissues (organs) c. No circulating Ab. involved, due to development T DH lymph “sensitized” d. Reactions delayed - ave. 24-48 hrs. after exposure to Ag. e. Reactions milder, persist longer period of time 2. Development of Delayed Hypersensitivities a. Primary Exposure: 1). Macrophage a). Processes antigen b). Presents antigenic determinants on cell membrane c). Secretes Interleukin I – attracts lymphocytes and macrophages 2). T H Lymphocytes a). Reacts with antigenic determinants b). Secretes Interleukin II – stimulates T DH lymphocytes 3). T DH Lymphocytes a). React with antigenic determinants b). Multiply clone immature lymphs c). Differentiate “sensitized” T DH lymphocytes b. Subsequent exposure: 1). “Sensitized” T DH lymphs react with allergen 2). Secrete lymphokines adverse reactions
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Unformatted text preview: 3). Lymphokines: a). Transfer factor sensitizes additional lymphocytes b). Lymphotoxin cytotoxic factor destroys host cells c). Macrophage Chemotactic Factor (MCF) attracts macrophages to site of reaction d). Macrophage Migration Inhibition Factor (MIF) keeps macrophages localized at site of reaction e). Macrophage Activating Factor increases activity macrophages angry macrophages 3. Types of Reactions a. Contact dermatitis 1). Allergens haptens complex with skin proteins 2). Absorbed through skin subcutaneous tissues 3). Reactions skin (red raised areas, itch) 4). Ex.: poison ivy b. Infectious allergies 1). Allergens intracellular bacteria (TB bacillus), systemic fungi, protozoans, helminths 2). Invade tissues delayed hypersensitivity c. Autoimmune disorders 1). Allergens host tissue cells 2). Destruction host tissue cells...
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This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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Delayed - 3). Lymphokines: a). Transfer factor sensitizes...

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