Disadvantages of Antimicrobial Therapy

Disadvantages of - overcomes action of AMA d R-factors(resistant genes in plasmids transferred to bacterial cells by conjugation transformation

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Disadvantages of Antimicrobial Therapy: 1. Allergic reactions 2. Toxic effects on normal tissues 3. Disturbs host normal flora secondary infections 4. Development of resistant strains – spontaneous mutations, DNA transfer a. Ability to destroy AMA by producing enzymes (Staph –penicillinase or β -lactamase) b. Mutations causing structural changes in cell so bypass metabolic step inhibited by AMA (L-forms - no cell wall) c. Over produce target molecules increase in quantity
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: overcomes action of AMA d. R-factors (resistant genes) in plasmids transferred to bacterial cells by conjugation, transformation, transduction F. Avoid disadvantages by: 1. Avoiding indiscriminate use of AMA 2. Maintain proper levels 3. For sufficient (prescribed) length of time 4. Use a combination of 2 or more AMA when resistance develops - synergistic effect 5. Do antibiotic sensitivity test to determine the most effective AMA...
View Full Document

This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

Ask a homework question - tutors are online