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Unformatted text preview: - rheumatic fever 4. Release of hidden or sequestered Ag. a. Not all Ag. . exposed to immune recognition system during embryonic development. b. If self-Ag. released into system later (due to injury, illness) → production of autoantibodies 5. Lack of T S lymph, dysfunction of T S lymph - As age # T S lymph decreases and # autoimmune diseases increases Genetic Defects of Immune System A. B-lymph defects → Agammaglobulinemia 1. Due to failure of B lymph to differentiate into plasma cells (Ab. producing cells) 2. The absence of immune receptors (IgD) on B lymphocytes B. T-lymph defects → DiGeorge syndrome 1. Failure to develop functional thymus gland 2. Do not cellular immunity 3. May develop low grade humoral immunity (hypogammaglobulinemia), C. T & B lymph defects - severe combined immunodeficiency disease (SCID) 1. Defect in stem cell - failure to develop mature T & B lymphocytes 2. Failure to develop immunity...
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- Fall '09
- Autoimmune Diseases, TS lymph, grade humoral immunity, immune receptors, lymph defects