Examples of agents and their actions

Examples of agents and their actions - Examples of agents...

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Examples of agents and their actions (see handout) a. Sulfonamides - Metabolic Pathway 1). Inhibits synthesis folic acid by competitive inhibition 2). Similar in structure to PABA – substrate for folic synthesis 3). Sulfa drugs compete with PABA for active site on enzyme 4) Sulfa drugs react with active site on enzyme 5). Inhibits enzyme and folic acid synthesis 6). Bacteriostatic b. Penicillin - Cell Wall Synthesis 1). Binds to & inhibits enzyme – penicillin-binding proteins 2). Inhibits formation peptide (amino acid) cross bridges 3). Inhibits formation bond between amino acid & muramic acid 4). Weakens cell wall lysis bacterial cell 5). Bactericidal c. Erythromycin Protein Synthesis 1). Binds to bacterial ribosome (protein) 2). Inhibits translocase – catalyzes movement codons (mRNA) on active site ribosome 3). “Freezes” mRNA on ribosome 4). Stops synthesis of protein (enzymes) 5). Bacteriostatic d. Tetracyclines - Protein Synthesis 1). Binds to bacterial ribosome 2).
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Examples of agents and their actions - Examples of agents...

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