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HOST CELL PARASITISM - b Viral DNA → viral m-RNA → host...

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HOST CELL PARASITISM : A. Source of nutrients 1. Amino acids production viral proteins 2. Nucleotides production viral cores B. Source of energy - ATP C. Sites of protein synthesis host cell ribosomes 1. Viral enzymes 2. Viral capsomeres 3. Envelope proteins REPLICATION OF ANIMAL VIRUSES - LYTIC CYCLE A. Adsorption 1. Virus attaches to host cell membrane. 2. Specific attachment – viral spikes complementary to host cell attachment sites B. Penetration 1. Virus enters host cell. 2. Phagocytosis, pinocytosis, fusion C. Uncoating (Eclipse) 1. Viral capsid dissolved by host cell enzymes. 2. Release of viral core. D. Synthesis of viral parts 1. Viral core redirects host cell metabolism 2. Viral parts produced (viral proteins & viral cores) E. Assembly (Maturation) 1. Assembly viral parts 2. Synthesis of mature virus particles. F. Release (Liberation) - Mature virus particles leave host cell. 1. Lysis of host cell naked viruses 2. “Budding” enveloped viruses G.Replication of: 1. DNA viruses a. Following uncoating, viral DNA core nucleus
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Unformatted text preview: b. Viral DNA → viral m-RNA → host cell ribosomes c. Viral proteins produced at host cell ribosomes d. Viral cores replicated in host cell nucleus e. Viral capsomeres transported into host cell nucleus f. Mature virus particles assembled in host cell nucleus 2. RNA viruses a. Following uncoating, viral RNA core remains in cytoplasm b. Viral RNA may function as m-RNA or produce m-RNA complementary to core c. Viral proteins produced at host cell ribosomes; capsomeres accumulate in cytoplasm of host cell d. Viral RNA cores replicated in host cell cytoplasm e. Assembly takes place in host cell cytoplasm → mature virus particles 3. Replication of Retroviruses a. Produce enzyme – reverse transcriptase b. Catalyzes reverse transcription c. RNA core in cytoplasm is template for production ½ DNA (one side) d. ½ viral DNA acts as template for complementary side DNA → viral DNA e. Viral DNA enters host cell nucleus → directs viral replication...
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