Hypersensitivities

Hypersensitivities - 1). Cell allergen + IgG (IgM) Cell Ag....

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Hypersensitivities (Allergies) d. Types reactions 1). Atopic (localized) reactions – allergic rhinitis (hay fever), asthma, uticaria (hives), G.I. tract, etc. 2). Systemic (generalized) reactions - anaphylaxis e. Desensitization 1). Allergy tests - skin tests a). Extracts allergens introduced under skin b). Observe for positive reaction -“wheal and flare” reaction (red, raised area) 2). Allergy “shots” a). Vaccine prepared containing allergens b). Injected in small amounts at regular intervals c). Stimulates formation IgG antibodies – “blocking antibodies” d). IgG reacts with allergens e). Prevents allergen binding to IgE on mast cells f). Host mast cells do not release histamine, heparin, etc. 4. Type II - Cytotoxic reactions a. Due to: 1). IgG, IgM – complement fixing antibodies 2). Complement system 3). Allergen – whole (intact) cells b. Primary exposure: 1). Cellular allergen IgG or IgM 2). Sensitized c. Subsequent exposure:
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Unformatted text preview: 1). Cell allergen + IgG (IgM) Cell Ag. Ab. complex 2). Cell Ag. Ab. complex + Complement Lysis cells, Inflammation d. Ex.: autoimmune diseases, transfusion reactions, Rh incompatibility, hemolytic disease of the newborn Type III - Immune complex reactions a. Due to: 1). IgG, IgM complement fixing antibodies 2). Complement system 3). Allergen - soluble antigen b. Primary exposure: 1). Soluble allergen IgG, (IgM) 2). Sensitized c. Subsequent exposure 1). Soluble allergen + IgG (IgM) Soluble Ag. Ab. complex 2). Soluble Ag. Ab. complex + Complement Lysis host cells, inflamation d. Types of reactions 1). Atopic reaction Arthus reaction a). Localized tissue damage b). Ex. soluble allergen tetanus toxoid booster 2). Systemic reactions Serum sickness a). Vessel wall damage b). Ex. soluble allergen horse antiserums...
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This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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Hypersensitivities - 1). Cell allergen + IgG (IgM) Cell Ag....

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