Inflammation - Fibrinogen in plasma fluids a Reacts to form...

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Inflammation 1. Generalized response following any type cell injury - trauma, chemical agents, physical agents, invasion by microbes 2. Functions a. Destroy and/or remove injurious agent b. Limits spread of injurious agent c. Repair or replace injured tissues 3. Description of process: a. Cellular injury 1). Injured cells release histamine and other chemicals 2). Initiates inflammatory response 3). Causes changes in capillaries and attracts cells. b. Changes in capillaries: 1). Increased vasodilation 2). Increased vascular permeability 3). Increased blood flow 4). Increased # PMN’s c. PMN’s 1). Margination - PMN’s adhere to capillary walls nearest site tissue injury 2). Diapedesis – PMN’s squeeze through capillary walls into tissues 3). Phagocytosis – PMN’s engulf and digest foreign material present in tissues. 4). PMN’s die and accumulate at site d. Macrophages 1). Migrate to site injury 2). Phagocytosis – foreign material and cellular (tissue) debris e. Plasma fluids 1). Leak from permeable capillaries and collect in tissues 2).
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Unformatted text preview: Fibrinogen in plasma fluids a). Reacts to form fibrin clots/strands b). Limits spread of pathogens/toxins present f. Fibroblasts – tissue repair 1). Connective tissue cells 2). Form new connective tissue → healing g. Accompanied by: 1). Edema - swelling a). Plasma fluids leak from permeable capillaries b). Plasma fluids accumulate in tissues 2). Pain a). Plasma fluids in tissues cause ↑ pressure on nerves b). Injury to nerves (wounds) 3). Calor – localized heat a). Increased enzyme activity of phagocytes → heat b). Increased blood flow 4). Hyperemia – localized redness a). Localized heat b). Dilation localized capillaries 5). Pus – accumulation of dead PMN’s (if microbes/foreign material present) F. Fever 1. Increase in body temperature: a. Inhibits growth of most viruses, some bacteria b. Increases metabolic reactions in host cells 2. Controlled by hypothalamus 3. Activated by pyrogens - released by microbes, injured host cells...
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This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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Inflammation - Fibrinogen in plasma fluids a Reacts to form...

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