LYSOGENY IN ANIMAL - c Provirus activated → lytic cycle virus replicates d Causes lysis host cells → viruses spread to healthy cells →

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LYSOGENY IN ANIMAL VIRUSES – LYSOGENIC (Latent, Dormant) CYCLE A. Provirus viral DNA permanently incorporated into host cell DNA B. Lysogeny 1. Provirus incorporated into host cell DNA 2. Provirus causes no change in: a. Host cell morphology b. Host cell metabolism 3. Provirus replicated with host cell DNA daughter cells 4. Provirus remains latent (dormant) until activated changes in host cell (recurrent infections, transformation) 5. Provirus activated by: UV, febrile illnesses, viral infections, chemicals, stress, fluctuations in production of sex hormones C. Effects 1. Recurrent (Latent) infections a. Following initial infection, provirus in host cells DNA in state of lysogeny b. Remains dormant until activated
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Unformatted text preview: c. Provirus activated → lytic cycle, virus replicates d. Causes lysis host cells → viruses spread to healthy cells → produces lesion e. Lesion heals → new tissue cells contain latent (dormant) provirus f. Provirus may be reactivated later → lesion reoccurs g. Ex. fever blisters, genital herpes, shingles 2. Transformation → neoplasms a. Provirus in host cells in latent state b. Provirus dormant until activated c. Provirus activated → affects host cells DNA (genes that control rate of growth) d. Host cells multiply at abnormal rate e. Abnormal (transformed) cells accumulate → form neoplasm (tumor)...
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This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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