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Unformatted text preview: - Enzyme activity is also influenced by (and, in living systems, is often regulated by) inhibitors (Tortora et al., Figure 5.6) = Competitive inhibitors are molecules that compete with the normal substrate for the enzyme's active site (Tortora et al., Figure 5.6b) = Noncompetitive inhibitors bind to a part of the enzyme other than the active site (Tortora et al., Figure 5.6c) The binding site of a noncompetitive inhibitor is called an allosteric site In some cases, allosteric binding of a compound can actually activate enzyme activity = Feedback inhibition (Tortora et al., Figure 5.7) is an important biochemical control mechanism involving allosteric noncompetitive inhibitors In feedback inhibition, the end-product of a reaction sequence acts as an allosteric inhibitor of an enzyme catalyzing a reaction early in the reaction sequence Feedback inhibition is especially important in regulating levels of metabolic intermediatesa...
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- Fall '09