NORMAL FLORA - B. Factors that influence organisms ability...

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NORMAL FLORA 5. Digestive tract a. Oral cavity, throat (oropharynx) - large flora b. Stomach - transient flora c. Small intestine 1). Duodenum - transient flora 2). Jejunum - small flora 3). Ileum - larger flora d. Colon (large intestine) - very large normal flora 6. Urinary tract a. Urethra - flora present, some are transient b. Bladder, ureter, kidneys - free of flora 7. Reproductive organs a. Male 1). Flora present in urethra 2). Internal organs free of flora b. Female 1). Flora present in vagina 2). Internal organs free of flora 8. Circulatory system a. Blood and lymph b. Free of organisms in healthy individual 9. CNS - no normal flora Microbial Invasiveness - How Microbes Cause Disease A. Invasiveness 1. Refers to microbe’s ability to overcome body defenses 2. Invade and cause disease
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Unformatted text preview: B. Factors that influence organisms ability to cause disease 1. Size of infecting dose - must be exposed to sufficient # organisms 2. Transmission a. Spread from host to host b. Depends on organisms ability to survive outside host 3. Portal of entry - organism must enter body in area in which it can grow, multiply (colonize) 4. Adherence to target tissue - pathogen must attach to host cells 5. Virulence of organism a. Measure of organisms ability to cause disease, severity of disease. b. Dependent on organisms invasiveness which is 1). Due to organisms physical and chemical characteristics 2). Enable organism to overcome body defenses, invade, produce injury...
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NORMAL FLORA - B. Factors that influence organisms ability...

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