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Peptic Ulcers of Stomach

Peptic Ulcers of Stomach - Immunity Temporary Vaccine...

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Peptic Ulcers of Stomach, Duodenum - Helicobacter pylori Gram neg. short spiral Virulence: Urea (product of protein metabolism) ammonia which neutralizes stomach acids. Disease: Migrates thru mucus coating of stomach lining attaches to cells reduces production of mucus inflammation. Complication: stomach cancer LOWER ALIMENTARY SYSTEM INFECTIONS Cholera - Vibrio cholera Gram neg., comma shaped Virulence: produces potent entero-exotoxin - causes cells m.m. of GI tract to lose large amts. fluids (up to 22 L/day) severe electrolyte imbalance. Transmission: Fecal-oral route - contaminated H 2 O, food Disease: localizes in small . Onset sudden - vomiting, abdominal pain, severe dysentery. Stools - cloudy fluids with mucus, organisms ("rice water stools") severe dehydration, electrolyte imbalance. High mortality rate (60%) - due to shock. Carrier state can occur after infection.
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Unformatted text preview: Immunity: Temporary Vaccine: Toxoid - not very effective Bacillary dysentery (Shigellosis) - Shigella species Gram neg. bacillus - 4 species pathogenic for man. S. dysenteriae- most virulent. S. sonnei- least virulent, most common in U.S. S. dysenteriae- Virulence: Endotoxins, exotoxins Transmission: Fecal-oral route H 2 O, food Disease: Inc. pd. 1-4 d. Organism localizes in large intestine → multiplies → invades m.m. causing ulceration, bleeding intestinal lining (no perforation) → severe inflammation → fluid loss → dysentery (stools mostly fluids with blood, pus, mucus), vomiting. Accom. by fever, severe abdominal pain, extreme weakness. Persists approx. 1 wk. - self-limiting. Complication: Can cause severe dehydration, electrolyte imbalance. Mortality rate high in infants, young children. No solid immunity. Vaccine: viable, oral - limited use...
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