This preview shows page 1. Sign up to view the full content.
Unformatted text preview: WOUND INFECTIONS Tetanus - Clostridium tetani Gram pos. bacillus, anaerobic, endospores, common in soil & GI tract animals Virulence: Powerful neurotoxin - blocks neurotransmitter inhibitor cholinesterase P/E: Endospores introduced deep into tissue wound (puncture wound) Disease: Inc. pd. 4 d. - 2 wk. Endospores germinate bacteria multiply at site, remain localized producing little or no inflammation secretes neurotoxin enters bloodstream CNS where interferes with cholinesterase causes tonic contractions, painful spasms of muscles. Onset: Headache, stiff neck, fever, chills. Spasms begin in muscles of face (causes difficulty in opening mouth) neck back chest abdomen extremities. Spasms can break bones, cause body contortions. Involvement of respiratory, cardiac muscles convulsions coma death. Vaccine: DPT toxoid Antitetanus antiserum also available - only neutralizes toxin in bloodstream....
View Full Document
- Fall '09