Unformatted text preview: WOUND INFECTIONS Tetanus - Clostridium tetani Gram pos. bacillus, anaerobic, endospores, common in soil & GI tract animals Virulence: Powerful neurotoxin - blocks neurotransmitter inhibitor cholinesterase P/E: Endospores introduced deep into tissue wound (puncture wound) Disease: Inc. pd. 4 d. - 2 wk. Endospores germinate → bacteria multiply at site, remain localized producing little or no inflammation → secretes neurotoxin → enters bloodstream → CNS where interferes with cholinesterase → causes tonic contractions, painful spasms of muscles. Onset: Headache, stiff neck, ↑ fever, chills. Spasms begin in muscles of face (causes difficulty in opening mouth) → neck → back → chest → abdomen → extremities. Spasms can break bones, cause body contortions. Involvement of respiratory, cardiac muscles → convulsions → coma → death. Vaccine: DPT toxoid Antitetanus antiserum also available - only neutralizes toxin in bloodstream....
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- Fall '09
- paralysis respiratory muscles