Typhoid fever - Typhoid fever (enteric fever) - Salmonella...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Typhoid fever (enteric fever) - Salmonella typhi Gram neg. bacillus Virulence: Endotoxins (cell wall lipids). Organisms invade m.m. & other organs enteric fever (begins in GI tract, enters blood, spreads throughout body). Transmission: Fecal-oral route P/E: Oral cavity - contaminated food, H 2 O Disease: Inc. pd. 1 - 3 wks. Organism localizes in small intestine invades m.m., lymphatic tissues (Peyers patches. In first week - fever, headache, malaise, diarrhea. In second week endotoxins cause ulceration intestinal wall (sometimes perforates) bloodstream septicemia spreads to other organs: (liver, kidneys, spleen, bone marrow, skin, gall bladder). Symptoms more acute - severe abdominal pain, severe diarrhea with blood, pus, weakness, abdominal distention. Other symptoms depend on organs infected. Rose spots in skin - due to multiplication organisms. Carrier state: Common following illness. Organisms remain in gall bladder - must be surgically removed to eliminate. Sporadic outbreaks - traced to carriers - food handlers
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/23/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

Ask a homework question - tutors are online