706_F06pset3 - 7.06 FALL 2006 Problem Set #3 1. Are SCF and...

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7.06 Fall 2006 PS 3 1 of 2 7.06 FALL 2006 Problem Set #3 1. Are SCF and APC the same thing as the proteasome? 2. What is the difference between . . . a. a centromere and a kinetochore? b. cohesin and condensin? c. a sister chromatid and a homolog? 3. a. What happens to G2/M cyclin protein levels if you express a version of the cyclin that lacks its destruction box? b. What happens to cell cycle progression in these cells? c. Would this be equivalent to what happens in a cell expressing a version of a G2/M cyclin that has all of its lysines mutated to alanines? 4. Before entry into S phase, a protein called Sic1p must be ubiquitinated and degraded in order to allow the cell cycle to progress. This protein is not ubiquitinated by APC but by another ubiquitin ligase complex called Cdc34-SCF. a. How would you determine what sequence in Sic1p, Cdc34-SCF binds to? b. Now that you know the sequence, how do you show it is sufficient to be recognized by Cdc34?
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This note was uploaded on 01/23/2012 for the course BIOLOGY lsm1301 taught by Professor Seow during the Spring '11 term at National University of Singapore.

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706_F06pset3 - 7.06 FALL 2006 Problem Set #3 1. Are SCF and...

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