7.06_2004_exam2 - Name: _______________________ 7.06 Spring...

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Unformatted text preview: Name: _______________________ 7.06 Spring 2004 Exam 2 1 of 10 7.06 Cell Biology Exam #2 March 18, 2004 Name: Student ID #: This is an open book exam, and you are allowed access to books, a calculator, and notes; but not computers or any other types of electronic devices. Please write your answers in pen (not pencil) to the questions in the space allotted; if you use the back of a sheet make it clear which answer is where. Be sure to put your name on each page in case they become separated! Remember that we will Xerox many exams at random. Good luck! Question 1. ___________________________ Question 2. ___________________________ Question 3. ___________________________ Question 4. ___________________________ Question 5. ___________________________ Question 1 (20 points) The wingless signaling pathway plays an essential role in pattern formation in most if not all metazoans. You therefore decided to collaborate with a micro-array Name: _______________________ 7.06 Spring 2004 Exam 2 2 of 10 facility to identify the transcriptional targets of this pathway. You send them several cell lines carrying loss of function mutations in known wingless signaling molecules. You ask them to analyze the expression profile using micro-array technology to obtain a clue as to the identity of the mutants. Your collaborator sends you the following primary data (note a filled circle means that the transcript is present, open circle means the transcript is absent): 1. (4 points) Describe how transcripts A, B, C and D are regulated by the wingless signaling pathway. 2. (5 points) Which important component(s) of the wingless pathway could be mutated in mutant 1? Name at least 3 and explain your reasoning. 3. (3 points) Which important component of the wingless pathway could be mutated in mutant 2? Name at least 1 and explain your reasoning. While you were analyzing your wingless mutants, your collaborator obtained a Name: _______________________ 7.06 Spring 2004 Exam 2 2 of 10 facility to identify the transcriptional targets of this pathway. You send them several cell lines carrying loss of function mutations in known wingless signaling molecules. You ask them to analyze the expression profile using micro-array technology to obtain a clue as to the identity of the mutants. Your collaborator sends you the following primary data (note a filled circle means that the transcript...
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7.06_2004_exam2 - Name: _______________________ 7.06 Spring...

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