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Unformatted text preview: produced by Clostridium botulinum, and tetanus toxin, produced by Clostridium tetani = Enterotoxins, such as the choleragen produced by Vibrio cholerae, interfere with fluid and electrolyte balance in gastrointestinal epithelium, leading to severe dehydration- Endotoxins are derived from lipopolysaccharides (LPS) from the cell walls of Gram-negative bacteria = Death of the bacterial cells leads to release of endotoxin, which is the lipid A portion of LPS = Endotoxin appears to act by causing release of interleukins (Tortora et al., Figure 15.5), which leads to a pyrogenic (fever-inducing) response by the host = If released in large amounts, endotoxins can lead to septic shock- Tortora et al. Figure 15.3 and Table 15.2 outline differentiation of exotoxins and endotoxin- Genes encoding production of exotoxins and other virulence factors may be encoded on plasmids or prophages carried by pathogenic bacteria...
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This note was uploaded on 01/24/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.
- Fall '09