Systems Microbiolo18

Systems Microbiolo18 - within a cell, so that one form can...

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Systems Microbiology ° Mechanisms and consequences of lateral gene transfer o Three methods: ° DNA transfer by phage ° DNA transfer by conjugation (uses pili) ° DNA transfer by transformation o These methods of transfer can all speed up the rate of mutation enormously o Thus huge genetic variation exists among these organisms ° Remember, only around 40% of E. coli DNA is shared among all three major E. coli strains o Map of genetic differences between Uropathogenic and enterohaemorrhagic E. coli ° Transfer RNAs are a place of frequent insertions o Molecular phylogenetics ° Making Phylogenetic trees – simply based on the number of sequence differences ° Requires certain conditions: • You must be comparing homologous sites and homologous sequences • Watch for paralogous genes – the result of a gene duplication
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Unformatted text preview: within a cell, so that one form can develop a different function, inside the same organism Homologous, on the other hand, implies the same gene function in different species These gene phylogies can be misleading if lateral gene transfer has occurred Phylogenic diagram showing lateral gene transfer o We cant just think about the genes that are inherited from parent cells the genes that microbes pick up from other microbes by lateral transfer is also prominent its a way of rapidly acquiring new traits It has big implications for the evolution of these organisms, particularly with antibiotic resistance. o Detecting horizontal transfers Not all genes are easily transferred...
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This note was uploaded on 01/24/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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