Systems Microbiolo21

Systems Microbiolo21 - codons and start to discover what the genes are o The range of the number of base pairs and genes stretch from around 400

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Systems Microbiology ° Genomics II o Comparative genomics basics o Gene calling o Bioinformatics web resources – there are a huge number of tools o Genomics of insect endosymbionts ° We each have around 10 14 microbes associated with us, that we carry around in our bodies o We all have our own genes that predispose us to certain diseases o It’s not that well understood how the human-associated microbe interacts with human genetics o There are some really neat studies going on right now involving how mice genetics determine which microbes live in the mouse’s gut ° Genomics is the starting point ° What do we do with a sequence, once assembled? o The first thing to do is to translate it into the reading frame – look at which
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Unformatted text preview: codons, and start to discover what the genes are o The range of the number of base pairs and genes stretch from around 400 protein encoding genes up to around 10,000. ° The organisms with the fewest genes are obligate endosymbionts ° The ones with the most genes are more metabolically versatile o Remember that bacterial and archeal genomes are circular. ° If you look at a bacterial sequence… o Table: Gene functional groups identified in the DNA sequence of E. coli K-12 o To this day, only around 60% of E. coli genes have been identified and described – and E. coli is the most well understood microorganism in the world ° This is getting better, but it’s still kind of a sobering thought....
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This note was uploaded on 01/24/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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