Systems Microbiolo24

Systems Microbiolo24 - more – it’s more like a factory...

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Systems Microbiology ° Genomics o DNA sequencing technology – things have really changed. There’s a real race going on for who can develop the best technology ° Human genome project: only around 30,000 genes in the human code. ° The day is not at all far off when doctors will read people’s genomes to discover what their inherent risks are. ° The human genome project involved two main groups – one more commercially based (J. Craig Venter – Celera), and one more public, open source, with funding from NIH (Francis Collins – NHGRI). Also the Sanger Centre, Whitehead Institute… ° The human genome project drove innovation in biotechnology. Two major technological benefits: o Stimulated development of high throughput methods – the assembly line. It’s not just the individual with a pipette any
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Unformatted text preview: more – it’s more like a factory approach (which matters for the social aspect of how science works). ° However, this might work back in the other direction as efficient machines develop… o Reliance on computational tools for data mining and visualization of biological information ° Biology is rapidly becoming informational science – bioinformatics and computational biology. ° DNA sequencing o Sanger’s technique ° Uses primer extension and DNA polymerase ° Dideoxynucleotides halt the replication at particular base pairs. Then you run for length on a slab gel, and you can tell which base pairs are at which locations, reading off the sequence and recording them manually....
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