Systems Microbiolo26

Systems Microbiolo26 - ° Slide Tryptophan ° Slide...

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Systems Microbiology ° To cover today: Genetic Exchange in Bacteria o Homologous recombination ° Promiscuous genetic exchange o Transformation o Plasmids and conjugation o Transposable elements o Transduction (virus mediated exchange) ° Three main mechanisms of gene exchange in bacteria: o Transformation ° Extracellular DNA uptake ° This was important historically in the discovery of what DNA actually is ° DNA that’s taken up can be used in different ways o Conjugation ° Bacterial mating systems ° This often involves pili o Transduction ° Virally mediated gene exchange ° Slide: RecA mediated homologous recombination
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Unformatted text preview: ° Slide: Tryptophan ° Slide: Transformation o Griffith’s experiment in 1928: the rough morphotype can kill the mice in the presence of the dead smooth mophotype o Slide: experiment by Avery, MacLeod, and McCarthy (1944) ° They repeated Griffith’s experiment in fractions. They found that the DNA from the smooth morphotype was the essential part – not the protein o Some species undergo transformation more easily than others. o Slide: the binding mechanisms involved in transformation ° Conjugation o Specialized pili involved, allowing the transfer of the DNA – the “pilus”...
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Systems Microbiolo26 - ° Slide Tryptophan ° Slide...

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