Systems Microbiolo28

Systems Microbiolo28 - o The genetic code has been inferred...

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Systems Microbiology ° Differences between eukaryotic and prokaryotic transcription o Archaea are very different from bacteria – they do it more like eukaryotes. o Eukaryotes do not have classical operons o Eukaryotic mRNAs are usually sliced, capped, and tailed, in the nucleus o RNA polymerase structure/function differ o Initiation complexes differ o These differences make good targets for antibiotics o Translation – prokaryotes are better in terms of rapid response – transcription and translation happen next to each other – they are coupled. In eukaryotes, one is in the nucleus, the other in the cytoplasm. ° Overview of Prokaryotic Translation o Slide: simple structure of a prokaryotic gene o Maintaining high enough fidelity for translation is really remarkable o Shine-Dalgarno sequence
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Unformatted text preview: o The genetic code has been inferred from lots of different experiments which codons code for which amino acids How this code could have occurred is really remarkable Originally it was assumed to be random, in the 1960s, but this doesnt seem to be the case, because it seems like there is some order to the groupings. Nobody really knows how it developed yet though. o Transfer RNAs o The early experiments that discovered how this works were really remarkable o The Genetic code is degenerate (meaning that multiple codons can code for the same amino acid). Sometimes there is a bias (in once cell, for example, UUU might be used for phenylalanine more often than UUC is used) Codon families exist. Also codon pairs. o Staying in the correct frame is critical....
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This note was uploaded on 01/24/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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