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Systems Microbiolo40

Systems Microbiolo40 - available for the peptidoglycan...

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Systems Microbiology ° Binary Fission o Time from bacterium to bacteria is a generation o Generation time is how long it takes o 20 minutes is a rather fast generation time. 8 minutes is the world record. o We look for bacteria that can replicate fast, or that can replicate in extreme conditions. o Cell content replicates before division. ° Fts proteins and the “divisome” o FtsZ aligns before division o The most intense signal occurs at the center edges due to the 3-dimensional shape ° Peptidoglycan synthesis o Peptidoglycan needs to be extgended for the cell to grow o The balance needs to be right, so cell integrity isn’t compromised o Antibiotics bind to DNA binding proteins like FtsI, so that those enzymes aren’t
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Unformatted text preview: available for the peptidoglycan synthesis, and the bacterium lyses. (Autolysins without autolysis) o The FtsZ ring leaves a scar in the cell wall, which you can see later ° Peptidoglycan structure o Two planes with cross-links in between. These cross-links give it its integrity o MreB allows a variety of shapes -- not just spheres ° Exponential Growth o Because bacteria undergo binary fission, they can replicate into mind-boggling numbers very fast (exponential rate) o After two days of unregulated growth one bacterium’s offspring would weigh more than the earth (assuming a 20 minute generation time) o Make a logarithmic plot of change in numbers as a function of time...
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