Systems Microbiolog1

Systems Microbiolog1 - eat its pretty stable People hadnt...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Systems Microbiology o Our genes determine how we respond to different microbes ° For example, when an appendix ruptures and releases microbes into the peritoneal cavity, it can make you very sick ° But when you inject these microbes into the peritoneal cavity of a rat, there are genes that influence whether it makes the rat very ill o Antibiotics put people at risk of thrush or yeast infections ° These microbes protect us, and without them we can get sick, such as with diarrhea or skin infections o We don’t know very much about our natural flora ° We don’t know exactly which microbes are there in what proportions ° Therefore it’s difficult to know how to restore these beneficial microbes after the use of antibiotics ° Some people say yogurt helps o The actual population of our gut does not change very much depending on what we
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: eat its pretty stable People hadnt originally expected this to be the case Model Systems o You can create germ-free animals by deriving them in an environment where there are no microbes around To do this, you do time-precise mating, birth them with a ceasarian section, and then keep them in a completely sterile environment You need to feed them every hour round the clock with a completely sterile milk or milk replacement so its very labor intensive o These animals will actually be able to grow and reproduce, though you have to supplement them with vitamin K and B12 o Mice have a large cecum, which contains a large population of microbes that will digest cellulose for them, so they can survive on poorer diets than we can...
View Full Document

This note was uploaded on 01/24/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

Ask a homework question - tutors are online