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Systems Microbiolog1 - eat – it’s pretty stable °...

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Systems Microbiology o Our genes determine how we respond to different microbes 􀂃 For example, when an appendix ruptures and releases microbes into the peritoneal cavity, it can make you very sick 􀂃 But when you inject these microbes into the peritoneal cavity of a rat, there are genes that influence whether it makes the rat very ill o Antibiotics put people at risk of thrush or yeast infections 􀂃 These microbes protect us, and without them we can get sick, such as with diarrhea or skin infections o We don’t know very much about our natural flora 􀂃 We don’t know exactly which microbes are there in what proportions 􀂃 Therefore it’s difficult to know how to restore these beneficial microbes after the use of antibiotics 􀂃 Some people say yogurt helps o The actual population of our gut does not change very much depending on what we
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Unformatted text preview: eat – it’s pretty stable ° People hadn’t originally expected this to be the case ° Model Systems o You can create germ-free animals by deriving them in an environment where there are no microbes around ° To do this, you do time-precise mating, birth them with a ceasarian section, and then keep them in a completely sterile environment ° You need to feed them every hour round the clock with a completely sterile milk or milk replacement – so it’s very labor intensive o These animals will actually be able to grow and reproduce, though you have to supplement them with vitamin K and B12 o Mice have a large cecum, which contains a large population of microbes that will digest cellulose for them, so they can survive on poorer diets than we can...
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