Systems Microbiolog4

Systems Microbiolog4 - they saw a decrease in resistant...

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Systems Microbiology ° Microbe-host interactions ° Antimicrobial drug resistance (from last week) o There are specific mechanisms that microbes can acquire to resist these chemicals o In the early 1950s people began to realize that all the old antibiotics were no longer working – multi-drug antibiotic resistance emerged and spread across the globe very quickly o There’s a lot of debate today about why we have this problem ° You would think that if you used enough of the drug for long enough, it would wipe out all the microbes before they had the chance to develop resistance ° Resistance often happens due to improper use of the drug, such as when patients stop taking antibiotics too soon ° A significant fraction of the antibiotics that are produced every year go into animal feeds, because it makes cattle, sheep, and pigs grow faster ° In Denmark, they prohibited all use of antibiotics in animal feeds, and
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Unformatted text preview: they saw a decrease in resistant microbes in hospitals Lobbies in the US would fight tooth and nail against a discontinuation of antibiotics in animal feed o R factors (resistance factors) If you look at old samples that were frozen before these antibiotics were produced by people, you can still find these R-factors They existed before, as resistance against factors produced by other bacteria But they were much more rare than they are today There are a number of microbial strains that are on the verge of being resistant to every drug we have available TB is an unusual bug It has to be treated with many different drugs at the same time There are often problems with patient compliance Patients infected with multi-drug-resistant strains of TB have the same risk of dying as patients with a regular strain do if they are untreated 50% will die...
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This note was uploaded on 01/24/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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