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Systems Microbiolog4 - they saw a decrease in resistant...

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Systems Microbiology 􀂃 Microbe-host interactions 􀂃 Antimicrobial drug resistance (from last week) o There are specific mechanisms that microbes can acquire to resist these chemicals o In the early 1950s people began to realize that all the old antibiotics were no longer working – multi-drug antibiotic resistance emerged and spread across the globe very quickly o There’s a lot of debate today about why we have this problem 􀂃 You would think that if you used enough of the drug for long enough, it would wipe out all the microbes before they had the chance to develop resistance 􀂃 Resistance often happens due to improper use of the drug, such as when patients stop taking antibiotics too soon 􀂃 A significant fraction of the antibiotics that are produced every year go into animal feeds, because it makes cattle, sheep, and pigs grow faster 􀂃 In Denmark, they prohibited all use of antibiotics in animal feeds, and
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Unformatted text preview: they saw a decrease in resistant microbes in hospitals ° Lobbies in the US would fight tooth and nail against a discontinuation of antibiotics in animal feed ° o R factors (resistance factors) ° If you look at old samples that were frozen before these antibiotics were produced by people, you can still find these R-factors • They existed before, as resistance against factors produced by other bacteria • But they were much more rare than they are today ° There are a number of microbial strains that are on the verge of being resistant to every drug we have available ° TB is an unusual bug • It has to be treated with many different drugs at the same time • There are often problems with patient compliance • Patients infected with multi-drug-resistant strains of TB have the same risk of dying as patients with a regular strain do if they are untreated – 50% will die...
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