Systems Microbiolog5

Systems Microbiolog5 - Systems Microbiology Antimicrobials...

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Systems Microbiology ° Antimicrobials used in vivo o Antibiotics are produced by microbes to inhibit the growth of other organisms ° Penicillium produced Penicillin, for example o Bacteriocins – produced by E. coli, for example, to act against other strains of E. coli ° A strain develops a resistance factor, and then develops a bacteriocin that kills all the other cells that don’t have that resistance ° This gives it an advantage over its neighbors o Arsenic was one of the first antimicrobials – used to treat syphilis o Sulfa drugs are not that useful anymore by themselves – resistance – cells have evolved the ability to use pre-formed folate o However, they can be used with trimethoprim – this and Sulfamethoxazole (“Septra”) work well together o Isoniazid – only used against tuberculosis ° Unusual lipids in the bacteria are targeted, and there’s no similar human biosynthetic pathway, so it’s very selective °
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This note was uploaded on 01/24/2012 for the course MCB MCB2010 taught by Professor Smith during the Fall '09 term at Broward College.

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Systems Microbiolog5 - Systems Microbiology Antimicrobials...

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