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Chap 51 notes - Chapter 51 FSH and LH FSH stimulates...

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Chapter 51 FSH and LH * FSH * stimulates follicle development * stimulates granulosa cells to produce estrogen * Endocrine, paracrine and autocrine mechanisms * LH * stimulates the theca cells to produce androgens (which are converted to estrogen) Estrogen * Responsible for primary and secondary female sex characteristics * Stimulates development of endometrium * Thicken and develop new blood vessels and glands After the First Week * Only one follicle continues to develop which secretes estrogen in the blood - * Estrogen * at relatively low concentration, but enough to: * inhibit pituitary FSH secretion by negative feedback * Acts on hypothalamus decreasing GnRH * Granulosa cells produce inhibin * also inhibits FSH secretion * During late preovulatory phase (middle of the cycle): Estrogen induces AP to secrete LH * This stimulates maturation of follicle and ovulation (ejection of secondary oocyte from ovary) * Follicle granulosa cells decrease estrogen production so estrogen concentration temporarily decreased
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