BIO 311c Ch14-DNA-Structure & Replication - Handout

BIO 311c Ch14-DNA-Structure & Replication - Handout...

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1 DNA Structure and Replication Mendelian Genetics Discovery of DNA as the Genetic Material DNA Structure Elucidation and Details DNA Replication Process DNA Repair Mechanisms K. Sathasivan Basic Terms DNA Genes/ alleles Locus Chromosome Genotype G-A-T-C C-T-A-G mRNA rRNA/ tRNA P o n AB, ab ,Ab Gametes Diploid cells/tissue/ organism Phenotype Random fertilization Recombination, Segregation and independent rRNA/ tRNA Protein (brown eye, pink flower, sickle cell) Meiosis Mitosis Law of Segregation Allele pairs segregate during gamete formation and the paired condition is restored during fertilization. Figure 14.1 A genetic cross Mendel tracked heritable characters for three generations
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2 Griffith’s Experiments Figure 11.2 Genetic Transformation by DNA (Part 1) Avery, McLeod and McCarty, 1944 – Transformation Experiment Figure 11.2 Genetic Transformation by DNA (Part 2) Hershey and Chase, 1952 – Phage Experiment Bacteriophage T2: Reproduction Cycle The Hershey–Chase Experiment (Part 1)
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3 The Hershey–Chase Experiment (Part 2) Figure 11.5 Transfection in Eukaryotic Cells Evidence so far Griffith’s experiment Mouse and R/S strain Avery and his group Transformation Hershey and Chase Phage with 32 P and 35 S DNA can transform eukaryotic cells Charagaff’s rule % of A=T; % of G=C Elucidation of DNA Structure Nucleotides Have Three Components repeat fig 3.23 here 5' end Deoxyribose (a 5-carbon sugar) Phosphate Adenine (A) Guanine (G) Purines (double-ring structures) Fig. 14-4, p. 281 3' end Thymine (T) Cytosine (C) Pyrimidines (single-ring structures)
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BIO 311c Ch14-DNA-Structure & Replication - Handout...

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