Unformatted text preview: proteins containing different amounts of either fibrinogen (Fg) or vWF under either static or flow conditions. How would you confirm that with increasing amounts of Fg or vWF in the plasma solution, you observe greater adsorption of each protein on the surface of the sample in both static and flow conditions? Why are you particularly interested in the proteins Fg and vWF? Explain in terms of the role of these proteins in blood coagulation. How would you determine the number of adherent platelets in each case (results are shown to the right)? You are asked to modify the PEG so that it deactivates either adsorbed Fg or adsorbed vWF. Based on the data presented, for this application, which protein is more important to deactivate and why? How would you do this? Problem #4) Describe the mechanism of drug delivery from a microsphere fabricated by the double emulsion technique using 50:50 molar ratio of PLG. How can you control the drug release kinetics?...
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- Fall '11
- Biomaterials, Platelets, vWF, polymer brush layer, double emulsion technique, proteins Fg