BioE+C118+_Fall+2011_+HW+5+Nov+1

BioE+C118+_Fall+2011_+HW+5+Nov+1 - proteins containing...

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MSE/BioE C118 (Fall 2011) HW #5 Due Date: Tuesday November 8, 2011 (Please hand-in HW in class) Problem #1) Describe the main differences between platelets and other mammalian cells. What changes occur within a platelet when it is activated? What differences can be observed in its morphology following activation? Which of the following two micrographs shows activated platelets (a or b)? Problem #2) Using concepts of a polymer brush layer, discuss how you would graft PEG to a surface to minimize protein adsorption. Address how solvent and temperature affect the organization of the PEO chains in solution? (You can assume the polymer coils do not interpenetrate). Problem #3) Suppose the coating in problem 2 is being evaluated as a surface modification to a PTFE vascular graft. You are responsible for testing the blood performance of your coating in #2. You perform an experiment in which you incubate your material with platelets suspended in a mixture of blood plasma
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Unformatted text preview: proteins containing different amounts of either fibrinogen (Fg) or vWF under either static or flow conditions. How would you confirm that with increasing amounts of Fg or vWF in the plasma solution, you observe greater adsorption of each protein on the surface of the sample in both static and flow conditions? Why are you particularly interested in the proteins Fg and vWF? Explain in terms of the role of these proteins in blood coagulation. How would you determine the number of adherent platelets in each case (results are shown to the right)? You are asked to modify the PEG so that it deactivates either adsorbed Fg or adsorbed vWF. Based on the data presented, for this application, which protein is more important to deactivate and why? How would you do this? Problem #4) Describe the mechanism of drug delivery from a microsphere fabricated by the double emulsion technique using 50:50 molar ratio of PLG. How can you control the drug release kinetics?...
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