HW+4 - MSE/BioE C118: Biological Performance of Materials...

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MSE/BioE C 118: Biological Performance of Materials Homework #4 Due 10/11/11 1. You are given an intraocular lens (IOL) lens that has been coated with a novel polymer to prevent cell growth over the lens while it is implanted. a. How would characterize the surface properties of the material prior to running any experiments to assess its biocompatibility? List at least three techniques and explain how they are used and what information they provide. b. Based on the Prime & Whitesides paper, what material would be a likely candidate for the coating? Justify your answer. c. What are the “new” themes for surfaces that resist protein adsorption? (20pts) 2. If you conduct a protein adsorption experiment where you increase the concentration of protein successively after the surface excess (mol/area) has reached equilibrium, you obtain the curves below comparing “direct” versus “successive” protein adsorption isotherms. Why does the successive experiment have much less protein adsorbed to the surface? Is the coating hydrophobic or
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HW+4 - MSE/BioE C118: Biological Performance of Materials...

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