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Ch2-Inflam - CHAPTER 2 Inflammation(5 OBJECTIVES 1(Concept...

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CHAPTER 2 Inflammation (5 OBJECTIVES) 1) (Concept) Understand the chain, progression, or sequence of vascular and cellular events in the histologic evolution of acute inflammation
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2) (Rote?) Learn the roles of various “chemical mediators” of acute inflammation 3) Know the three possible outcomes of acute inflammation 4) Visualize the three morphologic patterns of acute inflammation 5) Understand the causes, morphologic patterns, principle cells, minor cells, of chronic and granulomatous inflammation
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SEQUENCE OF EVENTS NORMAL HISTOLOGY VASODILATATION INCREASED VASCULAR PERMEABILITY LEAKAGE OF EXUDATE MARGINATION, ROLLING, ADHESION TRANSMIGRATION (DIAPEDESIS) CHEMOTAXIS PMN ACTIVATION PHAGOCYTOSIS: Recognition, Attachment, Engulfment, Killing (degradation or digestion) TERMINATION 100% RESOLUTION , SCAR , or CHRONIC INFLAMMATION are the three possible outcomes
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ACUTE INFLAMMATION “PROTECTIVE” RESPONSE NON -specific
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ACUTE INFLAMMATION VASCULAR VASCULAR EVENTS CELLULAR CELLULAR EVENTS (PMN or P oly M orphonuclear N eutrophil, Leukocyte?, “POLY”, Neutrophil, Granulocyte, Neutrophilic Granulocyte MEDIATORS” MEDIATORS”
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ACUTE INFLAMMATION Neutrophil Polymorphonuclear Leukocyte, PMN, PML “Leukocyte” Granulocyte, Neutrophilic granulocyte “Poly-” Polymorph
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Rubor Rubor Calor Calor Tumor Tumor Dolor Dolor 5 th (functio laesa) HISTORICAL HIGHLIGHTS (Egypt, 3000 BC)
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STIMULI for acute inflammation INFECTIOUS INFECTIOUS PHYSICAL PHYSICAL CHEMICAL CHEMICAL Tissue Necrosis Foreign Bodies (FBs) Immune “responses”, or “complexes”
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Vascular Changes Changes in Vascular Flow and Caliber Increased Vascular Permeability
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