Ch3-Regen

Ch3-Regen - REGENERATION HEALING (repair) LEARNING...

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REGENERATION HEALING (repair)
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LEARNING OBJECTIVES Review the normal physiology and concepts of cell proliferation , cell growth, cell “cycle”, and cell differentiation Understand the basic factors of tissue regeneration Understand the relationships between cells and their ExtraCellular Matrix (ECM) Understand the roles of the major players of healing--- angiogenesis, growth factors (GFs), and fibrosis Differentiate 1 st nd intention healing
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DEFINITIONS: REGENERATION: Growth of cells to replace lost tissues HEALING: A repar ative tissue response to a wound, inflammation or necrosis, often leads to fibrosis GRANULATION TISSUE “ORGANIZING” INFLAMATION
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REGENERATION Replacement of lost structures Is dependent on the type of normal turnover the original tissue has Can be differentiated from “compensatory” growth
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HEALING (repair) Needs a wound, inflammatory process, or necrosis Many disease appearances anatomically are the result of “healing” such as atherosclerosis Often ends with a scar Fibrosis, as one of the 3 possible outcomes of inflammation, follows “healing” Requires a connective tissue “scaffold” Fibrosis occurs in proportion to the damage of the ECM
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Cell Population Fates PROLIFERATION Hormonal, especially steroid hormones eg., EPO, CSF DIFFERENTIATION * UNIDIRECTIONAL, GAIN and LOSS APOPTOSIS * One of the most KEY concepts in neoplasia
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ECTODERM MESODERM ENTODERM
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CELL CYCLE G0 Quiescent (not a very long or dominent phase) G1 PRE-synthetic, but cell GROWTH taking place S Cells which have continuous “turnover” have longer, or larger S-phases, i.e., DNA synthesis S-phase of TUMOR CELLS can be prognostic G2 PRE-mitotic M (Mitotic:, P,M,A,T, Cytokinesis)
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CELL TYPES Labile: eg., marrow, GI Quiescent: liver, kidney NON-mitotic: neuron, striated muscle
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STEM CELLS (TOTIPOTENTIAL*) EMBRYONIC ADULT
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Ch3-Regen - REGENERATION HEALING (repair) LEARNING...

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