Ch6-Immune

Ch6-Immune - Diseases of IMMUNITY OBJECTIVES Differentiate...

Info iconThis preview shows pages 1–20. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Diseases of IMMUNITY OBJECTIVES Differentiate between the concepts of Innate and Adaptive immunity Visually recognize and understand the basic roles of lymphocytes, macrophages, dendritic cells, NK cells Understand the roles of the major cytokines in immunity Differentiate and give examples of the four (4) different types of hypersensitivity reactions OBJECTIVES Know the common features of autoimmune diseases, and the usual four (4) main features ( Etiology, Pathogenesis, Morphology, and Clin ) of S ystemic L upus E rythematosus, R heumatoid A rthritis, Sjgrens, Systemic Sclerosis (Scleroderma), M ixed C onnective Tissue D isease, and Poly- (aka, Peri-) -arteritis Nodosa Differentiate between Primary (Genetic) and Secondary (Acquired) Immunodeficiencies OBJECTIVES Understand the usual four (4) main features of AIDS, i.e., etiology, pathogenesis, morphology, clinical expression Understand the usual four (4) main features of Amyloidosis IMMUNITY INNATE (present before birth, NATURAL ) ADAPTIVE (developed by exposure to pathogens, or in a broader sense, antigens) MHC M ajor H istocompatibility C omplex A genetic LOCUS on Chromosome 6, which codes for cell surface compatibility Also called HLA (Human Leukocyte Antigens) in humans and H-2 in mice Its major job is to make sure all self cell antigens are recognized and tolerated, because the general rule of the immune system is that all UN-recognized cells will NOT be tolerated INNATE IMMUNITY BARRIERS CELLS: LYMPHOCYTES, MACROPHAGES, PLASMA CELLS, NK CELLS CYTOKINES /CHEMOKINES PLASMA PROTEINS : Complement, Coagulation Factors Toll-Like Receptors, TLRs ADAPTIVE IMMUNITY CELLULAR, i.e., direct cellular reactions to antigens HUMORAL, i.e., antibodies CELLS of the IMMUNE SYSTEM LYMPHOCYTES, T LYMPHOCYTES, B PLASMA CELLS (MODIFIED B CELLS) MACROPHAGES , aka HISTIOCYTES, (APCs, i.e., Antigen Presenting Cells) DENDRITIC CELLS (APCs, i.e., Antigen Presenting Cells) NK (NATURAL KILLER) CELLS L Y M P H S ANY ROUND CELL WITH RATHER DENSE STAINING NUCLEUS AND MINIMAL CYTOPLASM IN CONNECTIVE TISSUE, A BIT BIGGER THAN AN RBC, IS A LYMPHOCYTE UNTIL PROVEN OTHERWISE MACROPHAGE aka HISTIOCYTE MACROPHAGES are MONOCYTES that have come out of circulation and have gone into tissue MACROPHAGES, TEM, SEM ANY CELL MIXED IN WITH LYMPHOCYTES BUT HAS A LARGER MORE OPEN, LESS DENSE, LESS CIRCULAR NUCLEUS WITH MORE CYTOPLASM IS A MACROPHAGE UNTIL PROVEN OTHERWISE ALMOST ALL GRANULAR or PIGMENTED CELLS IN CONNECTIVE TISSUE ARE MACROPHAGES. GRANULOMAS, GIANT CELLS, ARE CHIEFLY MACROPHAGES ALSO. 1) ROUND NUCLEUS 2) OVOID CYTOPLASM 3) PERIPHERAL CHROMATIN 4) CLEAR ZONE BETWEEN NUCLEUS AND WIDER LIP OF CYTOPLASM PLASMA CELLS NK CELLS...
View Full Document

This note was uploaded on 01/25/2012 for the course PDBIO 305 taught by Professor Woods,a during the Fall '08 term at BYU.

Page1 / 81

Ch6-Immune - Diseases of IMMUNITY OBJECTIVES Differentiate...

This preview shows document pages 1 - 20. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online