Ch14-WBC

Ch14-WBC - DISEASES of WHITE CELLS and LYMPHOID TISSUE...

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Unformatted text preview: DISEASES of WHITE CELLS and LYMPHOID TISSUE Topics for Chapter 14 Leukopenia/Neutropenia Leukocytosis Lymphadenitis/Lymphadenopathy (Malignant) Lymphoma NON-Hodgkins Lymphoma Hodgkins Lymphoma (Hodgkins Disease) ALL/CLL (Acute/Chronic Lymphocytic Leukemia) Multiple Myeloma M1/M2/M3/M4/M5/M6/M7 Myeloproliferative Disorder CML and Polycythemia Vera Essential Thrombocytosis Splenomegaly Thymoma WBC/LYMPHOID DISORDERS Review of Normal WBC Structure/Function Benign Neutrophil and Lymphoid Disorders Leukemias Lymph Nodes Spleen/Thymus REVIEW NEUTROPHILS Normal TOTAL WBC count 6-11 K Neutrophils usually 2/3 of total normal Myeloblast Promyelocyte Myelocyte Metamyelocyte Band (stab) Mature Neutrophil (Poly, PMN, Neutrophilic Granulocyte) Produced in red (hematopoetic) marrow, sequester (pool) in spleen, live in peripheral blood, migrate OUT of vascular compartment PRN, live a couple days normally NEUTROPHIL Neutrophil Polymorphonuclear Leukocyte, PMN, PML Leukocyte Granulocyte, Neutrophilic granulocyte Poly- Polymorph NEUTROPHIL MATURATION LYSOSOMAL CONSTITUENTS PRIMARY Also called AZUROPHILIC, or NON-specific Myeloperoxidase Lysozyme (Bact.) Acid Hydrolases SECONDARY Also called SPECIFIC Lactoferrin Lysozyme Alkaline Phosphatase Collagenase FUNCTIONS Margination Rolling Adhesion Transmigration (Diapedesis) Chemotaxis Phagocytosis: Recognition, Engulfment, Killing (digestion) Equilibrium with splenic pool PELGER-HUET ANOMALY Genetic Sometimes ACQUIRED (Pseudo-PELGER- HUET) All neutrophils look like BANDS NOT serious, mostly a cute incidental finding CHEDIAK-HIGASHI SYNDROME Also genetic Abnormal LARGE irregular neutrophil granules Impaired lysosomal digestion of bacteria Associated with pigment and bleeding disorders CAN be serious, especially in kids LEUKO-penia/NEUTRO-penia Neutropenia/Agranulocytosis INADEQUATE PRODUCTION INCREASED DESTRUCTION 500-1000/mm3 is the DANGER zone! INADEQUATE PRODUCTION Stem cell suppression, e.g., aplastic anemias DRUGS, esp. CHEMO, MANY antibiotics, aminopyrene, thio-uracil, phenylbutazone DNA suppression due to megaloblastic/myelodysplastic states Kostmann Syndrome (genetic, congenital) Marrow usually shows granulocytic HYPO- plasia, just as in RBC and PLAT decreased production INCREASED DESTRUCTION Immune mediated By itself (idiopathic), or as in SLE After sensitization by many drugs Splenic sequestration, hypersplenism Increased peripheral demand, as in overwhelming infections, esp. fungal Marrow usually shows granulocytic HYPER- plasia, just as in RBC and PLAT increased destructions Leukocytosis/Neutrophilia Marrow and splenic pool size Rate of release between pool and circulation Marginating pool Rate of WBCs (neutrophils/monocytes)...
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This note was uploaded on 01/25/2012 for the course PDBIO 305 taught by Professor Woods,a during the Fall '08 term at BYU.

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Ch14-WBC - DISEASES of WHITE CELLS and LYMPHOID TISSUE...

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