Ch18-Liver

Ch18-Liver - Chapter 18 Chapter LIVER & BILIARY TRACT...

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Chapter 18 Chapter 18 LIVER LIVER BILIARY TRACT BILIARY TRACT
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DUCT SYSTEM
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N O FIBROUS TISSUE
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PORTAL “TRIAD” CENTRAL VEIN
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PATTERNS OF HEPATIC INJURY Degeneration: Balooning, “feathery” degeneration, fat, pigment (hemosiderin, bile, both intrinsic) Inflammation: Viral or Toxic Regeneration Fibrosis Neoplasia : 99% metastatic, 1% primary
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BALOONING DEGENERATION
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“FEATHERY” DEGENERATION
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FATTY LIVER
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“MICRO”-VESICULAR
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“MACRO”-VESICULAR STEATOSIS Obesity Diabetes Toxic
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“Golden” pigment stained with Prussian Blue stain to make it blue. Hemosiderin? Bile? Melanin?
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APOPTOSIS
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APOPTOSIS
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INFLAMMATION PORTAL TRIADS (early) SINUSOIDS (more severe)
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MILD “TRIADITIS”
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More severe portal infiltrates with sinusoidal infiltrates also
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Hepatic Regeneration The LIVER is classically cited as the most REGENERATIVE of all the organs!
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FIBROSIS FIBROSIS is the end stage of MOST chronic liver diseases, and is ONE (of TWO) absolute criteria needed for the diagnosis of cirrhosis. What is the other?
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CIRRHOSIS PORTAL-to-PORTAL (bridging) FIBROSIS The “normal” hexagonal “ARCHITECTURE” is replaced by NODULES
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CIRRHOSIS Liver Alcoholic Biliary (Primary or Secondary) Laennec’s Advanced (kind of a “redundant” adjective) Post-necrotic Micronodular Macronodular http://www.onelook.com/?w=*+cirrhosis&ls=a
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This note was uploaded on 01/25/2012 for the course PDBIO 305 taught by Professor Woods,a during the Fall '08 term at BYU.

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Ch18-Liver - Chapter 18 Chapter LIVER & BILIARY TRACT...

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