Ch24-Endocrine

Ch24-Endocrine - ENDOCRINE CLASSICAL ALGORHYTHM PITUITARY...

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ENDOCRINE
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CLASSICAL ALGORHYTHM PITUITARY ANTERIOR POSTERIOR THYROID PARATHYROID PANCREAS (endo.) ADRENAL CORTEX MEDULLA DEGENERATION (aka, “involution”) INFLAMMATION NEOPLASM BENIGN MALIGNANT
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BETTER ALGORHYTHM NON-NEOPLASTIC HYPER-function HYPO-function NEOPLASTIC FUNCTIONAL NON-FUNCTIONAL Functional endocrine malignancies are RARE. Why? PITUITARY ANTERIOR POSTERIOR THYROID PARATHYROID PANCREAS (endo.) ADRENAL CORTEX MEDULLA
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FEEDBACK SYSTEMS CORTEX, SUBCORTEX? HYPOTHALAMUS ANTERIOR PITUITARY ENDOCRINE GLAND END ORGAN HYPOTHALAMUS
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AntPit WiFi PostPit Wired
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HORMONES POLYPEPTIDE (2nd MESSENGER) STEROID (DIRECT on NUCLEUS)
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ACIDOPHILS BASOPHILS CHROMOPHOBES AXONS AXONS and “PITUI-”cytes A I P
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ANTERIOR PITUITARY ACIDOPHILS GROWTH HORMONE PROLACTIN BASOPHILS TSH ACTH LH, FSH
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POSTERIOR PITUITARY OXYTOCIN (contracts uterine smooth muscle) VASOPRESSIN (ADH) (vasoconstriction, gluconeogenesis, platelet aggregation, release of Factor-VIII and vWb factor, concentrates urine, main effects on kidney and brain)
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PITUITARY PATHOLOGY CLINICAL FEATURES, mimic the endocrine effects or mass effects) FUNCTIONING ADENOMAS HYPO-PITUITARISM POSTERIOR PITUITARY SYNDROMES HYPOTHALAMIC (SUPRASELLAR) TUMORS
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CLINICAL FEATURES HYPER: growth (a) , lactation (a) , thyroid (b) , adrenal cortex (b) HYPO: growth, thyroid, adrenal cortex MASS EFFECT: visual fields, brain
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G A L A C T O R R H E A
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GIGANTISM (excess somatotropin [GH] BEFORE epiphyseal closure)
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ACROMEGALY: (excess somatotropin [GH] AFTER epiphyseal closure)
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MOON FACIES BUFFALO HUMP STRIAE
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BITEMPORAL HEMIANOPSIA
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HYPO -pituitarism Pituitary tumors, functional or not. NON-pituitary tumors, primary or metastatic Pituitary surgery, of course Radiation, of course “Apoplexy”, i.e., sudden hemorrhage Sheehan’s syndrome (Post-partum ischemic necrosis) Cysts (Rathke’s cleft) Empty sella syndrome, (is NOT a disease) Genetic defects (pit-1 gene mutations)
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POSTERIOR pituitary DIABETES INSIPIDUS SIADH ( S yndrome of I nappropriate A ndi- D iuretic H ormone)
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DIABETES INSIPIDUS ADH deficiency Head trauma, tumors, inflam. hypothal/pit Hyperdiureses with LOW sp.gr.
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Inappropriate ADH ADH EXCESS Hyponatremia , cerebral edema, neurologic symptoms Neoplasms, esp. Small Cell CA. NON-neoplastic lung diseases Posterior pituitary injury
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15-25 grams
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This note was uploaded on 01/25/2012 for the course PDBIO 305 taught by Professor Woods,a during the Fall '08 term at BYU.

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Ch24-Endocrine - ENDOCRINE CLASSICAL ALGORHYTHM PITUITARY...

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