Ch28-CNS

Ch28-CNS - CNS CNS • Normal – Neurons – Glia •...

Info iconThis preview shows pages 1–52. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: CNS CNS • Normal – Neurons – Glia • Astrocytes • Oligodendrocytes • Ependymal Cells • Microglia • Pathology (13 Questions) Classical Disease Patterns • Degenerative • Inflammatory • Neoplastic Classical CNS Disease Patterns • Degenerative • Inflammatory • Neoplastic • Traumatic • 1) What are general patterns of CNS cell pathology? • 2) What are the consequences of ↓↑ CNS pressure ? • 3) What are common patterns of CNS malformations ? • 4) What are common perinatal CNS injuries? • 5) What are the patterns of CNS trauma ? • 6) What are the patterns of CNS vascular disease? • 7) What are the patterns of CNS infection ? ___________________________________________________ • 8) What are the patterns of CNS prion disease? • 9) What are the patterns of CNS demyelinating disease? • 10) What are the patterns of CNS degenerative disease? • 11) What are the CNS genetic metabolic diseases? • 12) What are the CNS acquired metabolic/toxic diseases? • 13) What are the CNS tumors ? CELLULAR REACTIONS • Neurons – Acute ( RED neuron, karyolysis) – Subacute, chronic, cell loss, gliosis – Axonal – Inclusions (lipid, prot., carb., viruses) • Glia, “gliosis” – Swelling – Fibers – Inclusions ACUTE NEURONAL INJURY “ RED ” NEURONS CEREBRAL EDEMA (normal weight 1200-1300 grams) • Vasogenic (disrupted BBB) – Intravascular INTER- cellular • Cytotoxic INTRA-cellular CEREBRAL EDEMA • Subfalcine ( SUPRA-tentorial ) • Cingulate ( TENTORIAL ) • Cerebellar tonsilar ( SUB-tentorial, or INFRA-tentorial ) • DDX : – EVERYTHING • SYMPTOMS – HEADACHE – HALLUCINATIONS – COMA – DEATH CEREBRAL EDEMA HYDROCEPHALUS HYDROCEPHALUS • Impaired RESORPTION • Increased PRODUCTION • OBSTRUCTION • COMMUNICATING (entire) • NON-COMMUNICATING (part) • HIGH Pressure • NORMAL Pressure CNS MALFORMATIONS • Neural Tube – Anencephaly, Encephalocele, Spina Bifida • Forebrain – Polymicrogyria, Holoprosencephaly, Agenesis of Corpus Callosum • Posterior Fossa (Infratentorial) – Arnold Chiari (infratentorial herniation), Dandy- Walker (cerebellar cyst) • Syringomyelia/Hydromyelia SPINA BIFIDA POLYMICROGYRIA HOLOPROSENCEPHALY SYRINGOMYELIA (note “ SYRINX ”) PERINATAL Brain Injuries • Intraparenchymal Hemorrhage • Intraventricular hemorrhage (premies) • Periventricular “leukomalacia” (i.e., infarcts) • Cerebral “Palsy” refers to nonprogressive diffuse cerebral pathology apparent at childbirth CNS TRAUMA • Skull Fractures • Parenchymal Injuries • Traumatic Vascular Injury • Sequelae • Spinal Cord Trauma BRAIN TRAUMA • Contusion (bruise) • Laceration (tear) • Coup/Contre-Coup • Concussion “HAIRLINE” “DEPRESSED”, aka “DISPLACED” HEMATOMAS/HEMORRHAGE • EPIDURAL (fx) • SUBDURAL (trauma NO fx) • SUBARACHNOID (arterial, no trauma) • INTRAPARENCHYMAL (any) • INTRAVENTRICULAR (no trauma, rare in adults, common in premies) EPIDURAL HEMATOMA SUBDURAL HEMATOMA...
View Full Document

This note was uploaded on 01/25/2012 for the course PDBIO 305 taught by Professor Woods,a during the Fall '08 term at BYU.

Page1 / 182

Ch28-CNS - CNS CNS • Normal – Neurons – Glia •...

This preview shows document pages 1 - 52. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online