Eukaryotes F

Eukaryotes F - during development . 10 Lewin 2000 Genes VII...

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1 Molecular Biology Part IV:Eukaryotes Regulation, Hyperdrive, & the C-Value Paradox F. Gene Families
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2 Gene Families Examples: rRNA, tRNA histones globins SINES
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3 Lewin 1990 Genes V
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4 rDNA families humans: 5S rRNA: ca. 2000 copies, chromosome 1 28S + 5.8S + 18S: 280 copies 5 clusters of 50-70 repeats each, one on each chromosome 13, 14, 15, 21, 22
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5 Watson et al. Recombinant DNA 2 nd ed. Look: ITS-1 Inter-genic spacer
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6 Watson et al. 1987 Mol. Bio. of the Gene 4 th ed
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7
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8 Lewin 2000 Genes VII Globin gene familiy: multiple copies of similar genes in two clusters
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9 Watson et al. Recombinant DNA 2nd ed. The order of human globin genes matches the order of their expression
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Unformatted text preview: during development . 10 Lewin 2000 Genes VII 11 Lewin 1990 Genes IV 12 Unequal crossing-over produces duplications and deletions 13 Lewin 2000 Genes VII Deletions in globin genes: thalassemias 14 Watson et al. Recombinant DNA 2nd ed. a-globin: a2 and psi-a1 pseudogene compared 15 Processed pseudogenes Another kind of pseudogene: no promoters! no introns! include poly-A tail! 16 Watson et al. 1987 Mol. Bio. of the Gene 17 Watson et al. 1987 Mol. Bio. of the Gene Humans: ca. 10 6 copies 3-6% of genome Alu I:--AG^CT----TC^GA--...
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Eukaryotes F - during development . 10 Lewin 2000 Genes VII...

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