Antioxidants_S10_Student

Antioxidants_S10_Student - Antioxidant nutrients What is a...

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Antioxidant nutrients
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What is a free radical? Molecule with 1 or more _unpaired electrons_ very unstable & highly reactive Free radical _steals electron_from another molecule Formerly stable molecule becomes unstable due to loss of electron Chain reaction
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Free radical formation Oxygen used in metabolic reactions Examples? Free radicals formed during _normal metabolism_ Exposure to _UV radiation_ Exposure to air pollution Exposure to tobacco smoke
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Effects of oxidative stress Aging Impaired _cognitive performance_ _Alzheimer’s?_ Cancer Arthritis Heart disease
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Antioxidant function Donate electron without becoming unstable break chain reaction Stimulate Aox enzyme activity Repair oxidative damage Stimulate activity of enzymes involved in repair
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Dietary antioxidants Vitamin C Vitamin E Beta-carotene Some phytochemicals Some minerals cofactors for antioxidative enzymes Selenium Copper Manganese Zinc
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Water-soluble Fat-soluble Absorption Directly into blood first into lymph Transport Travel freely Many require protein carriers Storage Circulate freely in water-filled parts of body Stored in cells associated with fat Excretion Excess excreted in urine Less readily excreted; tendency towards storage Toxicity Possible with supplement use likely with supplement use Requirements Needed frequently (ex: every 1-3 days) Needed in periodic doses (ex: weeks/months)
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Vitamin C Chapter 10: pp. 350-355
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Roles of vitamin C water-soluble antioxidant Cofactor in collagen formation Cofactor in other reactions Cure for the common cold? Protection from lead poisoning?
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Vitamin C as an Aox Aox for water-soluble substances Prevents iron oxidation in small intestine enhances iron absorption
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Vitamin C as antioxidant
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Exact role in stress unknown Vitamin C needs increased in stress Infections Burns
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This note was uploaded on 01/26/2012 for the course NTDT 200 taught by Professor Aljadir during the Fall '08 term at University of Delaware.

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Antioxidants_S10_Student - Antioxidant nutrients What is a...

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